Anti-SKP2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-SKP2 Polyclonal Antibody
中文名称： S期激酶相关蛋白2(p45)抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human
应用： IF ; WB
稀释比例： WB 1:100-500. IF 1:50-200.

抗体信息

靶标： SKP2
别名： p45skp2, skp2p45, p45, skp2 p45,S-phase kinase-associated protein 2, SKP2, CDK2/Cyclin A associated protein p45, Cyclin A/CDK2 associated protein p45, F box protein Skp2, F box/LRR repeat protein 1, FBL 1, FBL1, FBXL 1, FBXL1, FLB 1, FLB1, MGC1366, SKP2_HUMAN
背景说明： This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms.
Swiss Prot： Q13309
Gene ID： 6502
亚细胞定位： Cytoplasm Nucleus
免疫原： Recombinant protein of human SKP2
Public Immunogen Range： 100-200aa
理论分子量： 48kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

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