Iloprost；伊洛前列素,HPLC≥98%

产品属性 Product Attributes

基本信息

CAS 78919-13-8
中文名称: 伊洛前列素
英文名称: Iloprost
别名： Ciloprost;ZK 36374

分子式: C22H32O4

分子量: 360.49
规格: 5mg ; 2mg
溶解性： Soluble in DMSO
纯度： HPLC≥98%
外观(性状): Solid
储存条件: Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
运输条件: 冷藏运输

生物活性 以下数据均来自公开文献, ACMEC暂未进行独立验证, 仅供参考。

靶点 Prostaglandin Receptor

通路 Endocrinology & Hormones;GPCR & G Protein

背景说明:

是一种稳定的前列环素类似物。

生物活性:

Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue， involves in embryo development and inflammation improvement， and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research[1][2][3][4].

IC50: IP

In Vitro:

Prostacyclin (PGI2) is synthesised in oviductal fluid and enhance the embryo development[1].Iloprost is an PGI2 analog， and affects maturation and developmental competence of bovine oocytes[1].Iloprost (0.5 μM; 22-24 h) increases blastocyst rates of bovine embryos as well as proportion of expanded blastocysts[1].Iloprost (0.5 μM; 22-24 h) assists maturation rates and cumulus cell expansion of bovine oocytes， and increases the mRNA expression of genes related to cumulus expansion[1].Iloprost (0.5 μM; 22-24 h) reduces the occurrence of apoptosis in COCs and promotes an anti-apoptotic balance in the transcription of genes involved in apoptosis (BAX and BCL2) [1].In Vivo Iloprost (0.3 mg/kg/min; via s.c. mini pumps; 33 d) has a significant anti-metastatic activity in a spontaneously metastasizing tumor model in rat[2].Iloprost (0.2 mg/kg/d; i.p.; 10 d) attenuates hyperoxia effects and reduces inflammation in the newborn mouse lung， with Cyclooxygenase-2 (COX-2/PTGS2) mediates hyperoxia-induced impairment[3].Iloprost (0.2 mg/kg; i.v. or i.p.) exhibits short half-life， and is often administered by means of frequent (every 2-4h) inhalation in treatment[4].

数据来源文献

[1]. Kowalczyk-Zieba I， et al. Iloprost affects in vitro maturation and developmental competence of bovine oocytes. Theriogenology. 2020 Nov;157:286-296.

[2]. Hildebrand M. Pharmacokinetics of iloprost and cicaprost in mice. Prostaglandins. 1992 Nov;44（5）:431-42.

[3]. Olave N， et al. Iloprost attenuates hyperoxia-mediated impairment of lung development in newborn mice. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315（4）:L535-L544.

[4]. Schneider MR， et al. Effects of prostacyclin analogues in in vivo tumor models. Adv Prostaglandin Thromboxane Leukot Res. 1991;21B:901-8. 

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C储存时，请在1年内使用，-20°C储存时，请在6个月内使用。

产品介绍 Product Introduction

是一种稳定的前列环素类似物。

注意事项 Considerations

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