Recombinant Human IL-33,BR

产品属性 Product Attributes

基本信息

别名： Interleukin-33;IL-33;Interleukin-1 Family Member 11;IL-1F11;Nuclear Factor From High Endothelial Venules;NF-HEV;IL33;C9orf26;IL1F11;NFHEV
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件： The product is shipped at ambient temperature.

产品信息

背景说明： Interleukin-33 (IL-33) was initially discovered as a nuclear factor NF-HEV abundantly expressed in high endothelial venules.It is a 30-32 kD pro-inflammatory protein with intracellular and extracellular activities and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18.IL-33 is highly and selectively expressed by high endothelial venule endothelial cells (HEVECs) in human tonsils，Peyers's patches，and lymph nodes.It contains a bipartite nuclear localization signal at the C-terminus，and is targeted to the nucleus when ectopically expressed in human umbilical vein endothelial cells (HUVECs) and HeLa cells.The C-terminal fragment，corresponding to mature IL-33，binds and triggers signaling.IL-33 mediates its biological effects via Toll-interleukin 1 (IL-1) receptor (TIR) domain-containing receptor ST2，activates NF-kappaB and MAP kinases，and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells.In vivo，IL-33 induces the expression of IL-4，IL-5，and IL-13 and leads to severe pathological changes in mucosal organs.Human IL-33 is 270 amino acids in length.
来源： E.coli

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

产品介绍 Product Introduction

Recombinant Human Interleukin-33 is produced by our E.coli expression system and the target gene encoding Ser112-Thr270 is expressed.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。