Recombinant Human EGFR/HER1/ERBB1,BR

产品属性 Product Attributes

基本信息

别名： Epidermal growth factor receptor;Proto-oncogene c-ErbB-1;Receptor tyrosine-protein kinase erbB-1;EGFR;ERBB;ERBB1;HER1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件： The product is shipped at ambient temperature.

产品信息

背景说明： The EGFR subfamily of receptor tyrosine kinases is composed of EGFR，ErbB2，ErbB3 and ErbB4.The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily.All these family members are type I transmembrane glycoproteins with an extracellular ligand binding domain.The extracellular ligand binding domain is containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain.Ligand binding could induce EGFR homodimerization and heterodimerization with ErbB2，resulting in cell signaling，heterodimerization tyrosine phosphorylation and kinase activation.It can bind EGF，amphiregulin，TGF-alpha，betacellulin，epiregulin，HB-EGF，epigen，and so on.Its signaling regulates multiple biological functions including cell proliferation，differentiation，motility，and apoptosis.EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4.EGFR is overexpressed in different tumors.Several anti-cancer drugs use EGFR as target.
来源： Human cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

产品介绍 Product Introduction

Recombinant Human Epidermal Growth Factor Receptor is produced by our Mammalian expression system and the target gene encoding Leu25-Ser645 is expressed with a 6His tag at the C-terminus.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。