Recombinant Mouse PD-1/PDCD1(Fc fusion),BR

产品属性 Product Attributes

基本信息

别名： Programmed cell death protein 1;PD-1;CD279;Pdcd1;mPD-1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输条件： The product is shipped at ambient temperature.

产品信息

背景说明： Programmed Death-1 (PD-1)，firstly cloned from mouse T cell hybridoma 2B4.11，is one member of CD28/CTLA-4 superfamily.PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule.This family also include members of CD28，CTLA-4 and ICOS.The mouse Programmed Death-1 protein，encoded by PD-1 gene，comprises four parts including a putative 20 aa signal peptide，a 149 aa extracellular region，a 21 aa transmembrane domain and a 98 aa cytoplasmic region.The cytoplamsic tail of PD-1 contains two structural motifs，an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating.Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1.Recently，programmed death-1 (PD-1) with its ligands，programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2)，was found to regulate T-cell activation and tolerance，upon ligand binding，inhibiting T-cell effector functions in an antigen-specific manner.PD-1 gene knocked out mice would induce some autoimmune diseases，which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance.Thus，PD-1 may be a useful target for the immunologic therapy of carcinoma，infection，autoimmune diseases as well as organ transplantation.
来源： Human cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

产品介绍 Product Introduction

Recombinant Mouse Programmed Cell Death Protein 1 is produced by our Mammalian expression system and the target gene encoding Leu25-Gln167 is expressed with a Fc tag at the C-terminus.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。