Recombinant Human Indoleamine 2,3-Dioxygenase/IDO/INDO,BR

产品属性 Product Attributes

基本信息

别名： Indole 2;3-dioxygenase;Indoleamine 2;3-dioxygenase 1;IDO-1;IDO1;IDO;INDO
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 20mM Sodium Acetate, 150mM NaCl and 20% Glycerol, pH4.5.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
运输条件： The product is shipped on dry ice/ice packs.

产品信息

背景说明： Indoleamine 2，3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant，essential amino acid，l-tryptophan，along the kynurenine pathway.This protein is normally expressed in the dendritic cells，macrophages，microglia，eosinophils，fibroblasts，endothelial cells，and most tumor cells.IDO activity is associated with immunosuppression and immune attenuation.Several studies showed that IDO can contribute to immune escape when expressed directly in tumor cells or when expressed in immunosuppressive antigen presenting cells such as tolerogenic dendritic cells or tumor associated macrophages.IDO also is a promising therapeutic target for the treatment of cancer，chronic viral infections，and other diseases characterized by pathological immune suppression.
来源： E.coli

其它标识

内毒素: Less than 0.1 ng/g(1 IEU/g)as determined by LAL test.

产品介绍 Product Introduction

Recombinant Human Indoleamine 2,3-dioxygenase is produced by our E.coli expression system and the target gene encoding Met1-Gly403 is expressed with a 6His tag at the N-terminus.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。