小鼠基质金属蛋白酶8 ELISA试剂盒,BR

产品属性 Product Attributes

基本信息

中文名称： 小鼠基质金属蛋白酶8检测试剂盒
英文名称： Mouse MMP-8 ELISA Kit
别名： CLG1HNC; Collagenase 2; matrix metallopeptidase 8 (neutrophil collagenase); Matrix metalloproteinase-8; MMP8; MMP-8; neutrophil collagenase; PMNL collagenase; PMNL-CL
储存条件： 2-8℃，6 months
规格： 96T ; 48T
检测目标： MMP-8
样品类型： 血清/血浆/细胞培养上清
反应性： Mouse
应用： ELISA
定量/定性： 定量检测
精密度： 板内，板间变异系数均<10%
回收率： 80%-120%

Elisa信息

Swiss Prot： O70138
Gene ID： 17394
背景说明： Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade many components of the extracellular matrix. MMP-8 (neutrophil collagenase) is expressed in neutrophils, where it is stored in specific granules. MMP-8 release from the neutrophils is stimulated by various factors such as interleukins 1 and 8, TNF-alpha and GM-CSF. MMP-8 is capable of cleaving types I, II and III triple-helical collagen, gelatin peptides, fibronectin, proteoglycans, aggrecan, serpins, beta -casein and peptides such as angiotensin and substance P. In addition to its function in phagocytosis, MMP 8 has a high capacity for infiltrating connective tissue, and is implicated in the breakdown of the extracellular matrix in diseases such as rheumatoid arthritis. Structurally, MMP-8 consists of several domains: a pro-domain that is cleaved upon activation, a catalytic domain containing the zinc-binding site, a short hinge region and a hemopexin-like domain.

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