小鼠表皮生长因子受体3,BR

产品属性 Product Attributes

基本信息

中文名称： 小鼠表皮生长因子受体3检测试剂盒
英文名称： Mouse HER3/ERBB3 ELISA Kit
别名： Receptor Tyrosine Protein Kinase ErbB3; HER3; LCCS2; lethal congenital contracture syndrome 2; MDA-BF-1; MGC88033; Proto-oncogene-like protein c-ErbB-3
储存条件： 2-8℃，6 months
规格： 96T ; 48T
检测目标： HER3
样品类型： 血清/血浆/细胞培养上清
反应性： Mouse
应用： ELISA
定量/定性： 定量检测
检测范围： 93.75-6000pg/mL
灵敏度： 46pg/mL
精密度： 板内，板间变异系数均<10%
回收率： 80%-120%
反应时间： 3h15min

Elisa信息

Swiss Prot： Q61526
Gene ID： 13867
背景说明： ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

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