小鼠CD55分子检测试剂盒,BR

产品属性 Product Attributes

基本信息

中文名称： 小鼠CD55分子检测试剂盒
英文名称： Mouse CD55 ELISA Kit
别名： Cluster Of Differentiation 55; CD55; DAF; CD55 Antigen; CR; TC; CR0M
储存条件： 2-8℃，6 months
规格： 96T ; 48T
检测目标： CD55
样品类型： 血清/血浆/细胞培养上清
反应性： Mouse
应用： ELISA
定量/定性： 定量检测
检测范围： 7.8-500pg/mL
灵敏度： 3.9pg/mL
精密度： 板内，板间变异系数均<10%
回收率： 80%-120%
反应时间： 3h15min

Elisa信息

Swiss Prot： Q61475
Gene ID： 13136
背景说明： CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells. CD55 is physiologically acting as an inhibitor of the complement system, but is also broadly expressed in malignant tumours. DAF seems to exert different functions beyond its immunological role such as promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility. It is commonly hijacked by invading pathogens, including many enteroviruses and uropathogenic Escherichia coli, to promote cellular attachment prior to infection. This 70-75 kDa glycoprotein CD55 containing four SCR modules is involved in the regulation of the complement cascade. It inhibits complement activation by suppressing the function of C3/C5 convertases, thereby limiting local generation or deposition of C3a/C5a and membrane attack complex (MAC or C5b-9) production. DAF has been identified as a ligand for an activation-associated, seven-transmembrane lymphocyte receptor, CD97, which is a receptor mediating attachment and infection of several viruses and bacteria. In addition, it has been shown that DAF regulates the interplay between complement and T cell immunity in vivo, and thus may be implicated in immune and tumor biology.

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