猪骨形态发生蛋白1检测试剂盒,BR

产品属性 Product Attributes

基本信息

中文名称： 猪骨形态发生蛋白1检测试剂盒
英文名称： Porcine BMP1 ELISA Kit
别名： BMP1; BMP-1; EC 3.4.24; EC 3.4.24.19; FLJ44432; Mammalian tolloid protein; mTld; PCOLC; PCP; PCP2; procollagen C-endopeptidase; Procollagen C-proteinase; TLD
储存条件： 2-8℃，6 months
规格： 96T ; 48T
检测目标： BMP1
样品类型： 血清/血浆/细胞培养上清
反应性： Porcine
应用： ELISA
定量/定性： 定量检测
检测范围： 31.25-2000pg/mL
灵敏度： 15.6250pg/mL
精密度： 板内，板间变异系数均<10%
回收率： 80%-120%

Elisa信息

背景说明： Bone morphogenetic protein 1 (BMP1), is a protein which in humans is encoded by the BMP1 gene (1, 2). There are seven isoforms of the protein created by alternate splicing. BMP1 belongs to the peptidase M12A family of bone morphogenetic proteins (BMPs). It induces bone and cartilage development. Unlike other BMPs, it does not belong to the TGFβ superfamily. It was initially discovered to work like other BMPs by inducing bone and cartilage development. It however, is a metalloprotease that cleaves the C-terminus of procollagen I, II and III. It has an astacin-like protease domain. It has been shown to cleave laminin 5 and is localized in the basal epithelial layer of Porcine skin. The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely related to other known growth factors. BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. PCP or BMP1 protein cleaves the C-terminal propeptides of procollagen I, II, and III and its activity is increased by the procollagen C-endopeptidase enhancer protein. The BMP1 gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region.

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