大鼠骨形态发生蛋白1Elisa试剂盒,BR

产品属性 Product Attributes

基本信息

中文名称： 大鼠骨形态发生蛋白1检测试剂盒
英文名称： Rat BMP1 ELISA Kit
别名： BMP1; BMP-1; EC 3.4.24; EC 3.4.24.19; FLJ44432; Mammalian tolloid protein; mTld; PCOLC; PCP; PCP2; procollagen C-endopeptidase; Procollagen C-proteinase; TLD
储存条件： 2-8℃，6 months
规格： 48T ; 96T
检测目标： BMP1
样品类型： 血清/血浆/细胞培养上清
反应性： Rat
应用： ELISA
定量/定性： 定量检测
检测范围： 25-1600pg/mL
灵敏度： 5pg/mL
精密度： 板内，板间变异系数均<10%
回收率： 80%-120%

Elisa信息

Swiss Prot： A6HTK6
Gene ID： 83470
背景说明： Bone morphogenetic protein 1 (BMP-1), also known as procollagen C-proteinase (PCP), is a zinc protease of the astacin family. BMP-1/PCP plays a key role in formation of extracellular matrix (ECM) by converting precursor proteins into their mature and functional forms. The precursor proteins identified as substrates for BMP-1/PCP include collagens, biglycan, laminin 5, dentin matrix protein-1, and lysyl oxidase. There are six alternatively spliced forms known to be derived from the BMP-1 gene, and isoform 1 consisting of residues 1 to 730 was expressed. The secreted and purified protein does not contain the signal peptide (amino acid residues 1 22) and pro domain (residues 23 120), but contain protease (residues 121 321), CUB I (residues 322 434), CUB II (residues 435 546), EGF-like (residues 547 588) and CUB III (residues 591 703) domains. The pro domain is apparently cleaved by a furin-like proprotein convertase. The purified BMP-1/PCP is an active protease and its peptidase activity can be determined as described above. The purified BMP-1/PCP is predicted to possess procollagen C-proteinase activity because it contains the minimal domain structure required.

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