大鼠骨形态发生蛋白5Elisa试剂盒,BR

产品属性 Product Attributes

基本信息

中文名称： 大鼠骨形态发生蛋白5检测试剂盒
英文名称： Rat BMP5 ELISA Kit
别名： BMP5; BMP-5; bone morphogenetic protein 5; MGC34244
储存条件： 2-8℃，6 months
规格： 48T ; 96T
检测目标： BMP5
样品类型： 血清/血浆/细胞培养上清
反应性： Rat
应用： ELISA
定量/定性： 定量检测
检测范围： 83-6000pg/mL
灵敏度： 16pg/mL
精密度： 板内，板间变异系数均<10%
回收率： 80%-120%

Elisa信息

背景说明： Bone Morphogenetic Protein-5 (BMP-5) is one of at least 15 structurally and functionally related BMPs which are members of the transforming growth factor beta (TGF-beta ) superfamily. BMP-5 is synthesized as a 452 amino acid (aa) precursor protein that is cleaved at the dibasic cleavage site (RxxR) to release the 20 kDa C-terminal mature protein. Mature BMP-5 contains seven conserved cysteine residues involved in formation of the cysteine knot and the single interchain disulfide bond. Biologically active BMP-5 is a disulfide-linked homodimer of the C-terminal mature protein. Mature mouse BMP-5 shares 96% and 99% aa sequence identity with human and rat BMP-5, respectively. Cellular responses to BMP-5 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. BMP-5 is expressed by chondrocytes in proliferating and hypertrophic zones of bone growth plates. It contributes to limb development by promoting proliferation and differentiation of chondrocytes as well as apoptosis of undifferentiated mesoderm. Genetic defects in BMP-5 which cause C-terminal truncation or loss of the proteolytic cleavage site result in multiple skeletal abnormalities, including the short ear phenotype in mice. BMP-5 is also expressed by ovarian granulosa cells where it functions as an autocrine factor to promote GC proliferation and inhibit their production of progesterone. In the nervous system, BMP-5 promotes dendrite outgrowth and dopaminergic neuronal differentiation. It is upregulated in oral squamous carcinoma cells and induces the apoptosis of some myeloma cell lines.

产品介绍 Product Introduction

暂无数据

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。