Anti-Smad2 Monoclonal Antibody,BR

产品属性  Product Attributes

基本信息

英文名称：Anti-Smad2 Monoclonal Antibody

规格：100ul ; 50ul

宿主：Mouse

克隆类型：Monoclonal Antibody

亚型：IgG1

克隆号：6H5-E3-C11

交叉反应：Mouse ; Human

应用：IF ; ICC ; WB

稀释比例：WB 1:500-1000. IF 1:50-200. ICC 1:50-200.

抗体信息

靶标：Smad2

别名：hMAD-2;hSMAD2;JV18;JV18-1;MADH2;MADR2

背景说明：The protein encoded by this gene belongs to the SMAD,a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C.elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.This protein mediates the signal of the transforming growth factor (TGF)-beta,and thus regulates multiple cellular processes,such as cell proliferation,apoptosis,and differentiation.This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein.In response to TGF-beta signal,this protein is phosphorylated by the TGF-beta receptors.The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4.The association with SMAD4 is important for the translocation of this protein into the nucleus,where it binds to target promoters and forms a transcription repressor complex with other cofactors.This protein can also be phosphorylated by activin type 1 receptor kinase,and mediates the signal from the activin.Alternatively spliced transcript variants have been observed for this gene.[provided by RefSeq,May 2012]

Swiss Prot：Q15796

Gene ID：4087

亚细胞定位：Cytoplasm Nucleus

免疫原：Recombinant protein of human Smad2

理论分子量：60kDa

其它标识

纯化方法：Affinity purification

储存液：PBS with 0.02% sodium azide，0.5% BSA，50% glycerol，pH7.3.

储存条件：Store at -20℃. Avoid freeze / thaw cycles.

产品介绍  Product Introduction

使用前请离心。如有问题请及时联系我们。

Quick spin before use. If you have any questions, please contact us.

注意事项  Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。