Anti-ErbB2 Monoclonal Antibody,BR

英文名称:Anti-ErbB2 Monoclonal Antibody
宿主:Mouse
别名:CD340;HER-2;HER-2/neu;HER2;MLN19;NEU;NGL;TKR1
交叉反应:Transfected
应用:WB
稀释比例:WB 1:1000.
蛋白分子量:138kDa
Gene ID:2064
保存:Store at -20°C. Avoid freeze / thaw cycles.
储存液:Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法:Affinity purification
亚型:IgG1
免疫原:Purified recombinant human ErbB2 protein fragments expressed in E.coli.
性状:液体
亚细胞定位:Cell membrane Cytoplasm Nucleus Nucleus Single-pass type I membrane protein perinuclear region
Swiss Prot:P04626
克隆号:5B6-A9-C8
背景资料:This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
克隆类型:Monoclonal Antibody
规格:50ul, 100ul, 注意：
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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