Anti-TRAF2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-TRAF2 Polyclonal Antibody
中文名称： TNF受体相关因子2抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Human ; Mouse
应用： IHC ; WB
稀释比例： WB 1:500-2000. IHC 1:50-200.

抗体信息

靶标： TRAF2
别名： E3 ubiquitin-protein ligase TRAF2, TNF-R2, TNF R2, MGC:45012,
背景说明： The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
Swiss Prot： Q12933
Gene ID： 7186
亚细胞定位： Cytoplasm
免疫原： Recombinant protein of human TRAF2
Public Immunogen Range： 1-300aa
理论分子量： 56kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
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注意事项 Considerations

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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。