Anti-AKT1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-AKT1 Polyclonal Antibody
中文名称： 蛋白激酶B抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Rat ; Human
应用： IF ; IHC ; WB
稀释比例： WB 1:500-1000. IHC 1:50-200. IF 1:50-100.

抗体信息

靶标： AKT1
别名： AKT;CWS6;PKB;PKB-ALPHA;PRKBA;RAC;RAC-ALPHA
背景说明： The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
Swiss Prot： P31749
Gene ID： 207
亚细胞定位： Cell membrane Cytoplasm Nucleus
免疫原： A synthetic peptide of human AKT1
Public Immunogen Range： 350-480aa
理论分子量： 48/56kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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