Anti-PTEN Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-PTEN Polyclonal Antibody
中文名称： 同源性磷酸酶-张力蛋白抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Human
应用： IHC ; WB
稀释比例： WB 1:500-2000.IHC 1:50-100

抗体信息

靶标： PTEN
别名： 10q23del;BZS;CWS1;DEC;GLM2;MHAM;MMAC1;PTEN1;TEP1
背景说明： This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
Swiss Prot： P60484
Gene ID： 5728
亚细胞定位： Cytoplasm Nucleus PML body Secreted
免疫原： Recombinant protein of human PTEN
Public Immunogen Range： 224-403aa
理论分子量： 47kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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