Anti-TP53 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-TP53 Polyclonal Antibody
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Human ; Mouse
应用： IHC ; IF
稀释比例： IHC 1:50-200. IF 1:50-200.

抗体信息

靶标： TP53
别名： Trp53;TP53;bbl;bfy;bhy;p44;p53;
背景说明： This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined.
Swiss Prot： P02340
Gene ID： 22059
亚细胞定位： Endoplasmic reticulum Mitochondrion Nucleus
免疫原： Recombinant protein of human TP53
Public Immunogen Range： 95-390aa
理论分子量： 44kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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