Anti-CASP8 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-CASP8 Polyclonal Antibody
中文名称： 半胱氨酸蛋白酶8抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Rat ; Human
应用： WB
稀释比例： WB 1:500-1000

抗体信息

靶标： CASP8
别名： CAP4,Casp-8,FLICE,MACH,MCH5,Caspase 8,CASP8,Caspase-8,caspase-8
背景说明： This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
Swiss Prot： Q14790
Gene ID： 841
亚细胞定位： Cytoplasm
免疫原： A synthetic peptide of human CASP8
Public Immunogen Range： 300-400aa
理论分子量： 55/53/45/57/27/25/32/30/61kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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