Anti-FAS Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-FAS Polyclonal Antibody
中文名称： 肿瘤坏死因子受体超家族成员6抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human
应用： IF ; WB
稀释比例： WB 1:500-1000. IF 1:50-100.

抗体信息

靶标： FAS
别名： ALPS1A;APO-1;APT1;CD95;FAS1;FASTM;TNFRSF6
背景说明： The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Swiss Prot： P25445
Gene ID： 355
亚细胞定位： Cell membrane Secreted Single-pass type I membrane protein
免疫原： Recombinant protein of human FAS
Public Immunogen Range： 30-335aa
理论分子量： 38kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
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注意事项 Considerations

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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。