Anti-KIR2DL4 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-KIR2DL4 Polyclonal Antibody
中文名称： 杀伤细胞免疫球蛋白样受体2DL4抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Human ; Mouse
应用： WB
稀释比例： WB 1:500-1000.

抗体信息

靶标： KIR2DL4
别名： Killer cell immunoglobulin-like receptor 2DL4, MHC class I NK cell receptor KIR103AS, KIR103, CD158d, CD158 antigen like family member D, CD158D, G9P, Killer cell immunoglobulin like receptor, two domains, long cytoplasmic tail, 4 , Killer cell inhibitory receptor 103AS, KIR 103AS, KIR103AS, NK cell receptor, natural killer cell inhibitory receptor, KI2L4_HUMAN
背景说明： Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly.
Swiss Prot： Q99706
Gene ID： 3805
亚细胞定位： Cell membrane Single-pass type I membrane protein
免疫原： Recombinant protein of human KIR2DL4
Public Immunogen Range： 22-242aa
理论分子量： 41kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze / thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。