Anti-CHRNA7 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-CHRNA7 Polyclonal Antibody
中文名称： 烟碱型乙酰胆碱受体α7抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Rat ; Human
应用： IHC ; WB ; IF
稀释比例： WB 1:500-2000. IHC 1:50-200. IF 1:50-200

抗体信息

靶标： CHRNA7
别名： CHRFAM7A, ACHA7_HUMAN, cholinergic receptor, nicotinic, alpha 7, Neuronal acetylcholine receptor subunit alpha-7, ACHR ALPHA 7, AChR alpha 7 Receptor, Acra7, ALPHA-7NACHR, ALPHA7, ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR, Alpha7 nicr, BTX, CHRNA7, CHRNA7-2, NACHR alpha7, NACHRA7, NARAD, Alpha 7 neuronal nicotinic acetylcholine receptor FAM7A hybrid, CHRNA7 (cholinergic receptor nicotinic alpha 7 exons 5 10) and FAM7A (family with sequence similarity 7A exons A E) fusion, CHRNA7, CHRNA7 DR1, CHRNA7 FAM7A fusion, CHRNA7 FAM7A fusion protein, D 10, D10, MGC120482, MGC120483
背景说明： The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.
Swiss Prot： P36544
Gene ID： 1139
亚细胞定位： Cell junction Cell membrane Multi-pass membrane protein postsynaptic cell membrane synapse
免疫原： Recombinant protein of human CHRNA7
Public Immunogen Range： 23-230aa
理论分子量： 56kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。