Anti-PTPN1 Polyclonal Antibody,BR

英文名称:Anti-PTPN1 Polyclonal Antibody
宿主:Rabbit
别名:PTP1B;tyrosine-protein phosphatase non-receptor type 1

交叉反应:Human Mouse Rat
稀释比例:WB 1:500-2000. IHC 1:50-200. IF 1:10-100.
蛋白分子量:50kDa
Gene ID:5770
保存:Store at -20°C. Avoid freeze / thaw cycles.
储存液:Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法:Affinity purification
亚型:IgG
免疫原:Recombinant protein of human PTPN1
性状:液体
亚细胞定位:Cytoplasmic side Endoplasmic reticulum membrane Peripheral membrane protein
Swiss Prot:P18031
背景资料:

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.
Public Immunogen Range:Recombinant protein of human PTPN1
克隆类型:Polyclonal Antibody
规格:50ul, 100ul,

注意：
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