Anti-NR1I3 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-NR1I3 Polyclonal Antibody
中文名称： 核受体亚家族1, I组成员3抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Mouse ; Human
应用： IF ; WB ; IP
稀释比例： WB 1:500-1000. IF 1:50-200. IP 0.5μg-4μg.

抗体信息

靶标： NR1I3
别名： CAR, CAR BETA, CAR1, CARA, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, MGC97144, NR1I3, NR1I3_HUMAN, Nuclear receptor subfamily 1 group I member 3, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3
背景说明： This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
Swiss Prot： Q14994
Gene ID： 9970
亚细胞定位： Cytoplasm Nucleus
免疫原： Recombinant protein of human NR1I3
Public Immunogen Range： 103-352aa
理论分子量： 40kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
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注意事项 Considerations

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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。