Anti-TBP Polyclonal Antibody,BR

英文名称:Anti-TBP Polyclonal Antibody
宿主:Rabbit
别名:GTF2D;GTF2D1;HDL4;SCA17;TFIID
交叉反应:Human Mouse Rat
应用:WB
稀释比例:WB 1:500-2000.
蛋白分子量:38kDa
Gene ID:6908
保存:Store at -20°C. Avoid freeze / thaw cycles.
储存液:Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法:Affinity purification
亚型:IgG
免疫原:A synthetic peptide of human TBP
性状:液体
亚细胞定位:Nucleus
Swiss Prot:P20226
背景资料:Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene.
Public Immunogen Range:A synthetic peptide of human TBP
克隆类型:Polyclonal Antibody
规格:50ul, 100ul, 注意：
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