Anti-AXIN2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-AXIN2 Polyclonal Antibody
中文名称： 轴抑制蛋白2抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Rat ; Human
应用： IF ; IHC ; WB
稀释比例： WB 1:1000-5000. IHC 1:50-100. IF 1:50-200.

抗体信息

靶标： AXIN2
别名： Axil, Axin like protein, Axin-2, Axin-like protein, Axin2, Axis inhibition protein 2, AXIN2_HUMAN, Conductin
背景说明： The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Swiss Prot： Q9Y2T1
Gene ID： 8313
亚细胞定位： Cytoplasm
免疫原： Recombinant protein of human AXIN2
Public Immunogen Range： 743-843aa
理论分子量： 93kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.03% Proclin300，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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