Anti-PRKG1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-PRKG1 Polyclonal Antibody
中文名称： cGMP依赖性蛋白激酶1抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Human
应用： WB
稀释比例： WB 1:500-2000

抗体信息

靶标： PRKG1
别名： AAT8;PKG;PRKG1B;PRKGR1B;cGK;cGK 1;cGK1;cGKI;cGKI-BETA;cGKI-alpha
背景说明： Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
Swiss Prot： Q13976
Gene ID： 5592
亚细胞定位： Cytoplasm
免疫原： Recombinant protein of human PRKG1
Public Immunogen Range： 1-300aa
理论分子量： 76kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。