Anti-CBFB Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-CBFB Polyclonal Antibody
中文名称： 多瘤病毒增强了结合蛋白２β抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Rat ; Human
应用： IF ; IHC ; WB
稀释比例： WB 1:1000-5000. IHC 1:50-200. IF 1:50-200.

抗体信息

靶标： CBFB
别名： CBF b, CBF beta, CBF-beta, CBFbeta, Core binding factor beta subunit, core binding factor subunit beta, Core-binding factor subunit beta, PEA 2, PEA2, PEA2, PEA2 beta, PEA2beta, PEBB_HUMAN, PEBP 2B, PEBP2B, PEBP2 beta, PEBP2-beta, PEBP2B, PEBP2beta, Polyomavirus enhancer binding protein 2 beta subunit, SL3 3 enhancer factor 1 beta subunit, SL3 3 enhancer factor 1 subunit beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core binding factor beta subunit
背景说明： The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.
Swiss Prot： Q13951
Gene ID： 865
亚细胞定位： Nucleus
免疫原： Recombinant protein of human CBFB
Public Immunogen Range： 1-182aa
理论分子量： 22kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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