Anti-FKBP4 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-FKBP4 Polyclonal Antibody
中文名称： 热休克蛋白56抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Human ; Mouse
应用： IP ; IF ; IHC ; WB
稀释比例： WB 1:500-1000. IHC 1:50-200. IF 1:50-100. IP 0.5μg-4μg.

抗体信息

靶标： FKBP4
别名： FKBP51;FKBP52;FKBP59;HBI;Hsp56;PPIase;p52
背景说明： The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.
Swiss Prot： Q02790
Gene ID： 2288
亚细胞定位： Cytoplasm Mitochondrion Nucleus cytoskeleton cytosol
免疫原： Recombinant protein of human FKBP4
Public Immunogen Range： 220-459aa
理论分子量： 52kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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