Anti-IMPA1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-IMPA1 Polyclonal Antibody
中文名称： 肌醇-1-单磷酸酶1抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Human ; Mouse
应用： IF ; IHC ; WB
稀释比例： WB 1:500-2000. IHC 1:50-200. IF 1:10-100.

抗体信息

靶标： IMPA1
别名： IMP 1, IMP, IMPA 1, IMPA, IMPA1, IMPA1_HUMAN, IMPase 1, IMPase, Inositol 1(or 4) monophosphatase, Inositol monophosphatase 1, Inositol monophosphatase, Inositol(myo) 1(or 4) monophosphatase 1, Inositol-1(or 4)-monophosphatase 1, Lithium sensitive myo inositol monophosphatase A1, Lithium-sensitive myo-inositol monophosphatase A1
背景说明： This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
Swiss Prot： P29218
Gene ID： 3612
亚细胞定位： Cytoplasm Nucleus
免疫原： Recombinant protein of human IMPA1
Public Immunogen Range： 1-277aa
理论分子量： 30kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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