Anti-PIKFYVE Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-PIKFYVE Polyclonal Antibody
中文名称： 磷脂酰肌醇3磷酸激酶5Ⅲ型抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Human ; Mouse
应用： WB
稀释比例： WB 1:100-500.

抗体信息

靶标： PIKFYVE
别名： 1-phosphatidylinositol-3-phosphate 5-kinase,1 phosphatidylinositol 3 phosphate 5 kinase, 1 phosphatidylinositol 4 phosphate 5 kinase, CFD, FAB1, FYVE finger containing phosphoinositide kinase, KIAA0981, MGC40423, p235, Phosphatidylinositol 3 phosphate 5 kinase type III, Phosphatidylinositol 3 phosphate/phosphatidylinositol 5 kinase type III, Phosphatidylinositol 4 phosphate 5 kinase type III, Phosphoinositide kinase, FYVE finger containing, PIKFYVE, PIP5K, PIPkin III, PtdIns(4)P 5 kinase, Type III PIP kinase, ZFYVE29, Zinc finger, FYVE domain containing 29
背景说明： Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Swiss Prot： Q9Y2I7
Gene ID： 200576
亚细胞定位： Cytoplasm
免疫原： Recombinant protein of human PIKFYVE
Public Immunogen Range： 269-545aa
理论分子量： 237kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。