Anti-PYGL Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-PYGL Polyclonal Antibody
中文名称： 肝糖原磷酸化酶抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IP ; IF ; IHC ; WB
稀释比例： WB 1:500-1000. IHC 1:50-200. IF 1:50-200. IP 0.5μg-4μg.

抗体信息

靶标： PYGL
别名： Glycogen phosphorylase liver, Glycogen phosphorylase liver form, GSD6 antibody Hers disease, glycogen storage disease type VI, Phosphorylase glycogen liver, PYGL_HUMAN
背景说明： This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.
Swiss Prot： P06737
Gene ID： 5836
亚细胞定位： Cytosol secreted
免疫原： Recombinant protein of human PYGL
Public Immunogen Range： 690-847aa
理论分子量： 97kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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