Anti-NOTCH1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-NOTCH1 Polyclonal Antibody
中文名称： 跨膜受体蛋白Notch-1抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Human ; Mouse
应用： IF ; IHC ; WB
稀释比例： WB 1:500-1000.IHC 1:50-200.IF 1:50-200.

抗体信息

靶标： NOTCH1
别名： Notch 1 extracellular truncation, Notch 1 intracellular domain, hN1, Lin-12, LIN12, MIS6, Motch A, mT14, Neurogenic locus notch homolog protein 1, Neurogenic locus notch protein homolog, NICD, Notch1 intracellular domain, NOTC1_HUMAN, Notch 1, NOTCH, Notch gene homolog 1 (Drosophila), Notch homolog 1 translocation associated (Drosophila), Notch homolog 1, translocation-associated (Drosophila), NOTCH, Drosophila, homolog of, 1, notch1, p300, TAN 1, TAN1, TAN1, Translocation Associated Notch Homolog, Translocation Associated Notch Homolog, Translocation associated notch protein TAN 1, Translocation-associated notch protein TAN-1
背景说明： This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.
Swiss Prot： P46531
Gene ID： 4851
亚细胞定位： Cell membrane Nucleus Single-pass type I membrane protein
免疫原： Recombinant protein of human NOTCH1
Public Immunogen Range： 2456-2555aa
理论分子量： 273kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。