Anti-PSEN2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-PSEN2 Polyclonal Antibody
中文名称： 早老素蛋白-2抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Mouse ; Rat
应用： IF ; WB
稀释比例： WB 1:500-2000.IF 1:50-200

抗体信息

靶标： PSEN2
别名： AD 3L, AD 3LP, AD 4, AD 5, AD3L, AD3LP, AD4, AD5, Alzheimer disease 4, Alzheimer disease familial type 4, E5 1, Presenilin2, Presenilin 2, Presenilin 2, PS 2, PS2, PSEN 2, PSNL 2, PSNL2, STM 2, STM2
背景说明： Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
Swiss Prot： P49810
Gene ID： 5664
亚细胞定位： Endoplasmic reticulum membrane Golgi apparatus membrane Multi-pass membrane protein
免疫原： Recombinant protein of human PSEN2
Public Immunogen Range： 267-384aa
理论分子量： 50kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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