Anti-PSTPIP1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-PSTPIP1 Polyclonal Antibody
中文名称： 脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白1抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Mouse ; Human
应用： IHC ; WB
稀释比例： WB 1:500-2000. IHC 1:50-200.

抗体信息

靶标： PSTPIP1
别名： CD2 antigen binding protein 1, CD2 binding protein 1, CD2 cytoplasmic tail binding protein, CD2-binding protein 1, CD2BP1, CD2BP1L, CD2BP1S, H PIP, H-PIP, HPIP, PAPAS, PEST phosphatase interacting protein 1, PEST phosphatase-interacting protein 1, PPIP1_HUMAN, Proline serine threonine phosphatase interacting protein 1, Proline-serine-threonine phosphatase-interacting protein 1, PSTPIP, Pstpip1
背景说明： This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response.
Swiss Prot： O43586
Gene ID： 9051
亚细胞定位： Cell projection Cleavage furrow Cytoplasm cytoskeleton lamellipodium perinuclear region uropodium
免疫原： Recombinant protein of human PSTPIP1
Public Immunogen Range： 157-416aa
理论分子量： 48kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

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2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。