Anti-Phospho-FAS-Y291 Polyclonal Antibody,BR

英文名称:Anti-Phospho-FAS-Y291 Polyclonal Antibody
宿主:Rabbit
别名:ALPS1A;APO-1;APT1;CD95;FAS1;FASTM;TNFRSF6
交叉反应:Human
应用:WB
稀释比例:WB 1:500-2000.
蛋白分子量:38kDa
Gene ID:355
保存:Store at -20°C. Avoid freeze / thaw cycles.
储存液:Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法:Affinity purification
亚型:IgG
免疫原:A phospho specific peptide corresponding to residues surrounding Y291 of human FAS
性状:液体
亚细胞定位:Cell membrane Secreted Single-pass type I membrane protein
Swiss Prot:P25445
背景资料:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Public Immunogen Range:A phospho specific peptide corresponding to residues surrounding Y291 of human FAS
克隆类型:Polyclonal Antibody
规格:50ul, 100ul, 注意：
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