Anti-Phospho-PRKACA-T197 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-Phospho-PRKACA-T197 Polyclonal Antibody
中文名称： 蛋白激酶C抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Mouse ; Human
应用： WB
稀释比例： WB 1:500-2000.

抗体信息

靶标： Phospho-PRKACA-T197
别名： PPKACA;PKACA;PPNAD4;PKA C-alph
背景说明： This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Swiss Prot： P17612
Gene ID： 5566
亚细胞定位： Cell membrane Cell projection Cytoplasm Lipid-anchor Membrane Mitochondrion Nucleus cilium flagellum
免疫原： A phospho specific peptide corresponding to residues surrounding T197 of human PRKACA
理论分子量： 41kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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