Anti-CPEB4 (N-term) Polyclonal Antibody,BR

英文名称:Anti-CPEB4 (N-term) Polyclonal Antibody
宿主:Rabbit
别名:CPEB4 (N-term)
交叉反应:Human Mouse
应用:WB IHC-P
稀释比例:WB 1:1000. IHC 1:50-100.
蛋白分子量:80kDa
保存:Store at -20°C. Avoid freeze / thaw cycles.
储存液:Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法:Affinity purification
亚型:Ig
免疫原:synthetic peptide between 109-137 amino acids
性状:液体
亚细胞定位:Cytoplasm Cell membrane
Swiss Prot:Q17RY0
背景资料:Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).
Public Immunogen Range:synthetic peptide between 109-137 amino acids
克隆类型:Polyclonal Antibody
规格:50ul, 100ul, 注意：
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