Anti-IRAK1BP1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-IRAK1BP1 Polyclonal Antibody
中文名称： 白细胞介素1受体相关激酶1结合蛋白1抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Human
应用： IHC ; WB
稀释比例： WB 1:500-2000. IHC 1:25-100.

抗体信息

靶标： IRAK1BP1
别名： ActA binding protein 3, AIP70, IKBP1_HUMAN, Interleukin 1 receptor associated kinase 1 binding protein 1, IRAK1-binding protein 1, Signaling molecule that associates with Pelle-like kinase, SIMPL
背景说明： SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.
Swiss Prot： Q5VVH5
Gene ID： 134728
亚细胞定位： Cytoplasm
免疫原： Recombinant protein of human IRAK1BP1
理论分子量： 29kDa

其它标识

纯化方法： Affinity purification
储存液： pH7.4 PBS，0.05% NaN3，40% Glycerol.
储存条件： Store at -20℃. Avoid freeze / thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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