Anti-XAB2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-XAB2 Polyclonal Antibody
中文名称： XPA结合蛋白2抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IHC ; WB
稀释比例： WB 1:500-2000. IHC 1:25-100.

抗体信息

靶标： XAB2
别名： 0610041O14Rik, adapter protein ATH 55, Adapter protein ATH-55, Ath55, AV025587, Crn related protein kim1, crn-related protein kim1, DKFZp762C1015, HCNP, HCNP protein, HCRN, KIAA1177, NTC90, PP3898, Pre-mRNA-splicing factor SYF1, Protein HCNP, RNA splicing factor, SYF1, SYF1 homolog, SYF1 homolog, RNA splicing factor, SYF1_HUMAN, Xab2, XPA binding protein 2, XPA-binding protein 2
背景说明： HCNP, also known as XAB2 (Xeroderma pigmentosum group A (XPA) binding protein 2), HCRN, SYF1 or NTC90, is a nuclear protein that participates in transcription, transcription-coupled repair (TCR) and pre-mRNA splicing. It contains fifteen tetratricopeptide repeat motifs and associates with nucleotide excision repair machinery. More specifically, HCNP associates with Cockayne syndrome group A and B proteins (CSA and CSB), RNA Polymerase II (Pol II) and XPA in response to DNA damage and is believed to function in the TCR pathway. HCNP also functions as an essential component of a pre-mRNA splicing complex of the spliceosome (composed of AQR (aquarius), PRP19, CCDC16, HCNP, ISY1 and Cyclophilin E) and is required for proper RNA synthesis in the cell. In addition, HCNP functions as a component of the RAR corepressor complex with RAR and HDAC3 and exhibits an inhibitory effect on ATRA-induced cell differentiation. This suggests that HCNP may function as useful target in cancer therapy.
Swiss Prot： Q9HCS7
Gene ID： 56949
亚细胞定位： Nucleus
免疫原： A synthetic peptide of human XAB2
理论分子量： 100kDa

其它标识

纯化方法： Affinity purification
储存液： pH7.4 PBS，0.05% NaN3，40% Glycerol.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。