Anti-WWTR1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-WWTR1 Polyclonal Antibody
中文名称： 包含WW结构域转录调节因子1抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Mouse
应用： WB
稀释比例： WB 1:200-1000.

抗体信息

靶标： WWTR1
别名： Transcriptional co activator with PDZ binding motif, Transcriptional coactivator with PDZ binding motif, Transcriptional coactivator with PDZ-binding motif, WW domain containing transcription regulator 1, WW domain containing transcription regulator protein 1, WW domain-containing transcription regulator protein 1, WWTR 1, WWTR1, WWTR1_HUMAN
背景说明： The transcriptional co-activator with PDZ-binding motif (TAZ) is a 14-3-3-binding molecule. The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. TAZ may link events at the plasma membrane and cytosketeton to nuclear transcription in a manner that can be regulated by 14-3-3. TAZ shares homology with the WW domain of Yes-associated protein (YAP) and functions as a transcriptional co-activator by binding to the PPXY motif present on transcription factors. TAZ recognizes immunoreactive protein bands in lysates from MDCK, NIH-3T3 and 293T cells. In addition, COS7, Hep G2, CHO and HeLa cells express endogenous TAZ. 14-3-3 binding requires TAZ phosphorylation on a single Serine 89 residue, resulting in the inhibition of TAZ transcriptional co-activation through 14-3-3-mediated nuclear export.
Swiss Prot： Q9GZV5
Gene ID： 25937
亚细胞定位： Nucleus Cytoplasm Cell membrane
免疫原： A synthetic peptide of human WWTR1
理论分子量： 44kDa

其它标识

纯化方法： Affinity purification
储存液： pH7.4 PBS，0.05% NaN3，40% Glycerol.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。