Anti-CALR Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-CALR Polyclonal Antibody
中文名称： 钙网蛋白抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IHC ; WB
稀释比例： WB 1:1000-5000. IHC 1:50-200.

抗体信息

靶标： CALR
别名： Autoantigen RO, CALR, CALR protein, CALR_HUMAN, Calregulin, cC1qR, CRP55, CRTC, Endoplasmic reticulum resident protein 60, ERp60, grp60, HACBP, RO, Sicca syndrome antigen A, SSA
背景说明： Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.
Swiss Prot： P27797
Gene ID： 811
亚细胞定位： Cell surface Cytoplasm Endoplasmic reticulum lumen Sarcoplasmic reticulum lumen Secreted cytosol extracellular matrix extracellular space
免疫原： Recombinant protein of human CALR
理论分子量： 48kDa

其它标识

纯化方法： Affinity purification
储存液： pH7.4 PBS，0.05% NaN3，40% Glycerol.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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