Anti-DLAT Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-DLAT Polyclonal Antibody
中文名称： S-乙酰转移酶二氢脂酰胺抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IHC ; WB
稀释比例： WB 1:500-2000.IHC 1:30-150

抗体信息

靶标： DLAT
别名： DLAT, DLTA, E2, E2 component of pyruvate dehydrogenase complex, EC 2.3.1.12, M2 antigen complex 70 kDa subunit, M2 Antigen Complex 70kD Subunit, mitochondrial, ODP2_HUMAN, PBC, PDC E2, PDC-E2, PDCE2, Pyruvate dehydrogenase complex component E2, Pyruvate dehydrogenase complex E2 subunit, S acetyltransferase component of pyruvate dehydrogenase complex
背景说明： This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.
Swiss Prot： P10515
Gene ID： 1737
亚细胞定位： Cytoplasm
免疫原： Recombinant protein of human DLAT
理论分子量： 69kDa

其它标识

纯化方法： Affinity purification
储存液： pH7.4 PBS，0.05% NaN3，40% Glycerol.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
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注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。