Anti-LCN2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-LCN2 Polyclonal Antibody
中文名称： 脂质运载蛋白抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human
应用： WB
稀释比例： WB 1:1000-5000.

抗体信息

靶标： LCN2
别名： Lipocalin 2, Neutrophil Gelatinase associated Lipocalin, 25 kDa alpha 2 microglobulin related subunit of MMP9, Alpha 2 microglobulin related protein, HGNC:6526, HNL, Lcn 2, Lcn2, Neutrophil gelatinase associated lipocalin precursor, NGAL, Oncogene 24p3, P25, SV40 induced 24P3 protein. 24p3, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, Lipocalin-2, Migration stimulating factor inhibitor, MSFI, Neutrophil gelatinase associated lipocalin precursor, Neutrophil gelatinase-associated lipocalin, NGAL_HUMAN, Oncogenic lipocalin 24p3, Siderocalin, siderocalin LCN2, SV40 induced 24P3 protein
背景说明： Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Swiss Prot： P80188
Gene ID： 3934
亚细胞定位： Secreted
免疫原： A synthetic peptide of human LCN2
理论分子量： 23kDa

其它标识

纯化方法： Affinity purification
储存液： pH7.4 PBS，0.05% NaN3，40% Glycerol.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。