Anti-Aurora B Polyclonal Antibody,BR

英文名称:Anti-Aurora B Polyclonal Antibody
宿主:Rabbit
别名:STK-1;serine/threonine kinase 12;aurora-B;aurora-1;aurora kinase B-Sv1;aurora kinase B-Sv2;ARK-2; STK-1;STK1;aurora-related kinase 2;aurora/IPL1-related kinase 2;serine/threonine-protein kinase aurora-B;aurora- and Ipl1-like midbody-associated protein 1;AURKB;AIK2;AIM-1;AIM1;ARK2;AurB;aurkb-sv1;aurkb-sv2;IPL1;STK12;STK5;AIRK2;AURKB_HUMAN
应用:WB ELISA Flow-Cyt
稀释比例:WB 1:500-2000. ELISA 1:500-1000. Flow-Cyt 3μg/Test.
蛋白分子量:39 kDa
保存:Store at -20°C. Avoid freeze / thaw cycles.
储存液:Buffer: PBS with 0.03% sodium azide, 50% glycerol, pH7.4.
纯化方法:Affinity purification
亚型:IgG
免疫原:KLH conjugated synthetic peptide derived from human Aurora B
亚细胞定位:Cytoplasm Nucleus
Swiss Prot:Q96GD4
背景资料:Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis. A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity.
克隆类型:Polyclonal Antibody
规格:50ul, 100ul, 注意：
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