Anti-P53(wt-p53) Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-P53(wt-p53) Polyclonal Antibody
中文名称： 肿瘤蛋白P53抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Mouse ; Human预测
交叉反应：： Pig;Cow;Horse;Rabbit;Sheep
应用： ELISA ; FCM ; IF ; ICC ; IHC ; WB
稀释比例： WB 1:500-2000. ELISA 1:5000-10000. IHC 1:100-500. FCM 1μg/Test . ICC 1:100. IF 1:100-500.

抗体信息

靶标： P53(wt-p53)
别名： Widespread p53;Wtp53;Antigen NY-CO-13;Cellular tumor antigen p53;Cys 51 Stop;HGNC11998;LFS1;p53;p53 Cellular Tumor Antigen;p53 Tumor Suppressor;Phosphoprotein p53;TP53;Transformation related protein 53;TRP53;Tumor protein p53;Tumour Protein p53;P53_HUMAN;TP53.
背景说明： Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Swiss Prot： P04637
Gene ID： 7157
亚细胞定位： Cytoplasm Endoplasmic reticulum Mitochondrion matrix Nucleus PML body
免疫原： A synthetic peptide of human P53(wt-p53)
Public Immunogen Range： 251-310/393aa
理论分子量： 23/30/34/38/44kDa

其它标识

纯化方法： Affinity purification
储存液： 0.01M TBS(pH7.4) with 1% BSA，0.03% Proclin300 and 50% Glycerol.
储存条件： Store at -20℃. Avoid freeze / thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

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