Anti-PCNA Polyclonal Antibody,BR

英文名称:Anti-PCNA Polyclonal Antibody
宿主:Rabbit
别名:Proliferation Marker;Cyclin;DNA polymerase delta auxiliary protein;HGCN8729;MGC8367;Mutagen-sensitive 209 protein;Pcna/cyclin;PCNAR;Polymerase delta accessory protein;Proliferating Cell Nuclear Antigen;PCNA_HUMAN
交叉反应:Human Mouse Rat Chicken Dog Cow Rabbit
应用:WB ELISA IHC-P IHC-F Flow-Cyt IF
稀释比例:WB 1:500-2000. ELISA 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. Flow-Cyt 1μg/Test. IF 1:100-500.
蛋白分子量:29kDa
Gene ID:5111
保存:Store at -20°C. Avoid freeze / thaw cycles.
储存液:Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法:Affinity purification
亚型:IgG
免疫原:KLH conjugated synthetic peptide derived from human PCNA
亚细胞定位:Nucleus
Swiss Prot:P12004
背景资料:Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
克隆类型:Polyclonal Antibody
规格:50ul, 100ul, 注意：
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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