Anti-RELA Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-RELA Polyclonal Antibody
中文名称： 细胞核因子/k基因结合核因子抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Mouse ; Human预测
交叉反应：： Pig;Cow
应用： ELISA ; FCM ; IF ; ICC ; IHC ; WB
稀释比例： WB 1:500-2000. ELISA 1:5000-10000. IHC 1:100-500. FCM 2ug/Test. ICC 1:100-500. IF 1:100-500.

抗体信息

靶标： RELA
别名： NF kB P65;NF-kB p65;NF-kB-p65;NFKBp65;NF-κBp65;NF-kBp65;Avian reticuloendotheliosis viral (v rel) oncogene homolog A;MGC131774;NFKB 3;NFKB3;RELA
背景说明： NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1.
Swiss Prot： Q04206
Gene ID： 5970
亚细胞定位： Cytoplasm Nucleus
免疫原： A synthetic peptide of human RELA
Public Immunogen Range： 101-200/551aa
理论分子量： 59/60kDa

其它标识

纯化方法： Affinity purification
储存液： 0.01M PBS with 15mM Sodium Azide,1% BSA，pH 7.4
储存条件： Store at -20℃. Avoid freeze / thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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