Anti-TAP2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-TAP2 Polyclonal Antibody
中文名称： 转运蛋白2抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Human预测
交叉反应：： Rat;Dog;Pig;Cow;Horse;Rabbit
应用： FCM ; ELISA
稀释比例： FCM 1μg/Test. ELISA 1:5000-10000.

抗体信息

靶标： TAP2
别名： ABC18;ABCB3;Peptide supply factor 2;Peptide transporter PSF2;Peptide transporter TAP2;PSF2;RING 11;TAP 2;Transporter 2 ATP binding cassette sub family B
背景说明： TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It is a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP is inducible by interferon gamma and belongs to the ABC transporter family, MDR subfamily. TAP also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. It is inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding.
Swiss Prot： Q03519
Gene ID： 6891
亚细胞定位： Cell membrane
免疫原： A synthetic peptide of human TAP2
Public Immunogen Range： 451-550/686aa
理论分子量： 75kDa

其它标识

纯化方法： Affinity purification
储存液： 0.01M TBS(pH7.4) with 1% BSA，0.03% Proclin300 and 50% Glycerol.
储存条件： Store at -20℃. Avoid freeze / thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。