Anti-Aurora B Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-Aurora B Polyclonal Antibody
中文名称： 极光激酶B抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Human预测
交叉反应：： Rat;Pig;Cow;Horse;Rabbit
应用： ELISA ; FCM ; WB
稀释比例： WB 1:500-2000. ELISA 1:5000-10000. FCM 3ug/Test.

抗体信息

靶标： Aurora B
别名： STK-1, serine/threonine kinase 12, aurora-B, aurora-1, aurora kinase B-Sv1, aurora kinase B-Sv2, ARK-2, STK-1, STK1, aurora-related kinase 2, aurora/IPL1-related kinase 2, serine/threonine-protein kinase aurora-B, aurora- and Ipl1-like midbody-associated protein 1, AURKB, AIK2, AIM-1, AIM1, ARK2, AurB, aurkb-sv1, aurkb-sv2, IPL1, STK12, STK5, AIRK2, AURKB_HUMAN
背景说明： Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis. A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity.
Swiss Prot： Q96GD4
Gene ID： 9212
亚细胞定位： Nucleus Cytoplasm
免疫原： A synthetic peptide of human Aurora B
Public Immunogen Range： 51-150/344aa
理论分子量： 39kDa

其它标识

纯化方法： Affinity purification
储存液： 0.01M TBS(pH7.4) with 1% BSA，0.03% Proclin300 and 50% Glycerol.
储存条件： Store at -20℃. Avoid freeze / thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。